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The Latest Proven Techniques To Treat Wrinkled Aging Skin And For Soft Tissue Augumentation

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(For the price of the each product please click on the appropriate logo)

Topics

(PRICING AND LITERATURE)
Restylane, Perlane
Maridur, Matigel, Matidex
Dermalive® & Dermdeep®
Aquamid FAQ
Aphrodite Gold

Subtopics


Dermal Fillers
Discover which wrinkle treatment is best for you and your situation
Dermal Filler product comparison
All About the different available Dermal Fillers pros and cons
What is aging skin?
Aging Skin Glossary
Cosmetic Procedures
FAQ

Injectables for sub-dermal augmentation:


PRODUCT SPECIFICATIONS:
Description: a syringe filled with 0.7cc viscose gel-like material. This material contains pmma microbeads suspended in atelo collagen 3.5%. A syringe is packed in an individual tube, 4 tubes, 4 patient ID labels and four 26 Gauge and two 30 Gauge needles are packed in a tray. The tray is stored in an unit box .
Aphrodite Gold  is the latest in permanent to long lasting injectable implants. Consist of non migratory PMMA micro-spheres coated in Atelocollagen, thus minimizing risk of allergic reactions & increasing safety.

Sterilization method: aseptic production
Composition: Content: 0.7cc per syringe
Polymethylmethacrylate (PMMA) microbeads (25%)
3,5% atelo collageen (75%),
Set of 4 x 26 G needles and 2 x 30G needles
Artecoll is a collagen base loaded with no migratory PMMA microspheres making it a long lasting to "permanent" solution.
  Aquamid is a permanent solution. Aquamid is a transparent polyacry-lamide gel with an extremely high water content allowing natural elasticity and hydration in surrounding tissue.
A safe, cost effective polydensified monophasic product that fills wrinkles and integrates into the surrounding dermis for an immediate lifting effect on the entire area treated.

Please note: There is a standard charge for shipping and handling per consignment, regardless of the size of your order or its point of destination.
 
Juvederm is cross-Linked Hyaluronic Acid available in 5 different variations for superficial, medium depth and deep dermis treatment. Two variations are High Viscosity, specially developed for a longer lasting effect and smoother injection experience.
Juvelift is a hyaluronic acid solution for mesolift  - an overall skin management process. Injected into the dermal-epidermal junction or the superficial dermis, exogenous hyaluronic acid rapidly reaches the dermis resulting in recolonisation of the extra-cellular matrix, improved skin elasticity and disappearance of fine lines.
Restylane, Perlane and Restylane Touch is a three fold product variation of non animal, stabilized hyaluronic acid gel for superficial, middle and deep dermal treatment.
Long lasting Dermalive and Dermadeep are made of flexible particles of acrylic hydrogel and hyaluronic acid of non-animal origin.
For orders of 20 or more a discount of 10% may be taken For orders of 50 or more a discount of 20% may be taken
Matridur, Matridex , MatriGel
HylaNew Hyaluronic Acid
Phigel Wrinkles
Phigel Lips
Surgical Implants:  
Pure gold filaments implanted sub dermally as a skin tenser or body filler. The gold threads have braided polyglycolic acid as support and promote gradual encapsulation by the connective tissue. Youth-making effects that last from 5 to 10 years and can be repeated.
Permacol surgical implant is acellular cross-linked collagen derived from porcine dermis which when implanted into the human body, is non-allergenic and permanent. Used in the field of  surgical reconstruction, re-contouring and repair of human tissue. Permacol is also available as an injectable urethral bulking agent.
High quality, sterile, single use, smooth or textured mammary implants made up of pre-filled saline, pre-filled hydrogel and pre-filled high cohesivity gel.
Sclerotherapy:  

Sclerovein sclerosant is a painless and highly effective treatment by injection, of  Spider and varicose veins.

Externally used products:  
ROC® RETINOL ACTIF PUR® Anti-Wrinkle Cleansing Lotion Helps Wash Away Appearance of Fine Lines and Wrinkles

RoC Retinol Actif Pur Day Cream
Price:
RETINOLACTIF PUR (R) Anti Wrinkle cleansing lotion by 50 ml is USD32
And RETINOLACTIF PUR (R) Day spf 15 by 30ml is USD50
RENOVA RETIN-A ANTIAGING/ ANTIACNE  CREAM Generic Renova 20 mg 0.025% Tretinoin USD 28.00 only
Generic Renova 20 mg 0.05% Tretinoin USD20.00 only
Generic Renova 15 mg 0.01% gel Tretinoin USD 30.00 only
Phoebe Cream is an innovative and effective face-periorbital / day-night cream, which prevents and reverses the clinical signs of both photo and intrinsic aging. It is sold in 50ml bottles equipped with a pump action dispenser.
Kelagel Anti-Hematoma Chelating Gel. A brilliant ointment for post operative damaged skin that normalizes the residual post-Inflammatory pigmentation.
Silgel serves to protect and help in the healing of damaged or scarred skin tissue and has become one of the best management methods of hypertrophic / keloid scar and associated erythema.
CityLips Gently Stimulates Lips to Produce Their Own Collagen & Hyaluronic Acid For Larger, Sexier Lips. The exclusive formula delivers instant moisture, increases lip volume and reduces unattractive lip wrinkles and fine lines. (Highly recommended as an enhancer to post lip augmentation implants or on its own as a lip plumper.)

For orders of 20 or more a discount of 10% may be taken For orders of 50 or more a discount of 20% may be taken.

Restylane and Other Injectables At-A-Glance

Facial Injectables

As more and more injectable materials become available, there is a great deal of confusion about what each one does, which injection to get, and for what purpose. The following may clarify some of the confusion and provide valuable information for someone who may be considering an injectable material.

Currently, demand for injectable materials come from people looking for a treatment for fine lines or wrinkles, enlarging lips, and improving the appearance of scarring. Injectable materials offer a “non-invasive”, inexpensive, “quick-fix” that many people find to be an extremely easy way to have smoother, younger looking skin.

For centuries, physicians and patients have sought non-surgical therapies to remove or reduce the appearance of facial wrinkles and aging. Many materials have been tried; some with good results, others with disastrous results and others have proven ineffective. The products mentioned below represent a partial listing of injectables receiving ongoing attention.

As the largest plastic surgery organization in the world and the foremost authority on cosmetic and reconstructive plastic surgery, the American Society of Plastic Surgeons (ASPS) welcomes the introduction of new and exciting therapies and products. The society however, cautions that without meaningful scientific evaluation, physicians may be unwilling to use products until there is convincing evidence of their safety and efficacy.

Since the 1980s, injectable collagen has been used as a soft-tissue filler. Collagen is a naturally occurring protein that supports various parts of the body including skin, tendons and ligaments. Commonly used injectable collagen is made from purified cow skin to fill wrinkles, lines and scars on the face. The primary risk of injectable collagen is allergic reaction. Injectable collagen absorbs into the body. More than 576,000 people had collagen injections in 2003, according to the ASPS.

Injectable Description Purpose Possible Side Effects/Risks Results Regulatory Status
Zyderm/ Zyplast Collagen injection made from purified cow skin. Fills wrinkles, lines and scars on face and around lips. Allergic reaction. Requires skin test prior to procedure. Immediate, lasts up to 6 months. FDA Approved

Human Tissue Derived Collagen

A group of human-derived collagen products are currently available in the United States. The tissue, harvested using sterile techniques from donors or grown in a laboratory, are processed to form an injectable human collagen matrix.

Injectable Description Purpose Possible Side Effects/ Risks Results Regulatory Status
Cymetra (Micronized Alloderm) Injectable human tissue collagen matrix derived from cadaver tissue, screened for contami-nation. Filler for lips, nasolabial folds, deep wrinkles and lines. Bruising Multiple treatments needed; lasts 2 months FDA Approved
CosmoDerm/ CosmoPlast Derived from human tissue that has been purified and grown in a laboratory. Doesn't need a skin test. Approved for frown lines, crow's feet, forehead lines, smile lines, vertical lip lines, marionette lines, lip border and for certain scars. Cosmoderm is used for superficial lines, while Cosmoplast is used for more pronounced wrinkles. Bruising Immediate,
lasting up to six months depending on the area treated
FDA Approved
Fascian Injectable derived from donor-fascia (connective tissue made of collagen) of the thigh muscle. Stimulates collagen formation, adds bulk. Bruising Lasts up to 6 months FDA Approved
Autologen Injectable collagen prepared from the patient's skin. Small pieces of skin are harvested from the patient, processed and prepared for injection or frozen for later use. An alternative to traditional collagen injections. Bruising, time consuming and expensive 2 or 3 treatments over a 6 to 8 week period to produce collagen; not permanent Not required

Human Derived Product

Injectable Description Purpose Possible Side Effects/ Risks Results Regulatory Status
Plasmagel Plasma emulsion (protein) made of patient's blood and Vitamin C complex. Soft tissue filler to add volume. Bruising Lasts up to 3 months Not required

Fat

Fat injections have been used for years to add volume, fill wrinkles, lines and enhance the lips. Fat injections involve taking fat from one part of the patient's body (abdomen, thighs or buttocks) and reinjecting it beneath the facial skin. Unlike bovine collagen, allergic reaction is not a factor as the fat is harvested from the patient's own body. Results are variable, but can be permanent. More than 61,000 individuals had fat injections in 2003, according to the ASPS.

Botulinum toxins

Botulinum toxins have been used for neck spasms, cranial nerve disorders and eye spasms. With the recent FDA approval of Botox for cosmetic use in the glabellar region, the drug is used to smooth wrinkles. When injected into facial muscles botulinum toxins block nerve impulses, temporarily paralyzing muscles and smoothing wrinkles. Currently Botox® is the only form of botulinum toxin approved by the FDA for cosmetic purposes in the glabellar region, but two others, MyoblocTM and Dysport® are under FDA review for cosmetic use.

More than 2.8 million Botox® injections were performed in 2003, according to ASPS. Botox injections were the most popular cosmetic minimally invasive procedure in 2003. Fifty-seven percent of all Botox® procedures were performed on people between the ages of 35 –50.

Injectable Description Purpose Possible Side Effects / Risks Results Regulatory Status
Botox Botulinum toxin type A Smoothes wrinkles, reduces hyperhydrosis Bruising, numbness, droopy eyelids, body may become immune Can begin to take effect 5-7 days, maximum effect in two weeks FDA approved for use in the glabellar region.

All other use considered off label.
Myobloc Botulinum toxin type B; Requires larger dose than Botox but takes effect more quickly. Myobloc has a longer shelf life than Botox. May serve as alternative to patients resistant to botulinum toxin type A. Smoothes wrinkles Bruising, numbness, droopy eyelids, body may become immune Can take effect in 4-6 hours, maximum effect in 2 weeks In use outside U.S.

FDA approved only for cervical dystonias.

All other use considered off label.
Dysport Botulinum toxin type A; Requires larger dose than Botox but manufacturer claims injections are stronger and last longer with patients returning twice a year rather than four treatments with Botox. Smoothes wrinkles Bruising, numbness, droopy eyelids, body may become immune Can begin to take effect 5-7 days, maximum effect in two weeks In use outside the U.S. FDA decision pending.

Hyaluronic Acid

Hyaluronic acid exists naturally in all living organisms and is a natural component of connective tissues, including the skin. Hyaluronic acid has been used to treat joint pain. Restylane® is a soft tissue filler made of hyaluronic acid, manufactured by recombinent technology which adds volume to minimize wrinkles and lines. As the substance naturally occurs in humans and all animals, allergic reactions are rare. According to the ASPS, more than 44,000 people had Restylane injections in 2003. Captique™ is another soft tissue filler made of hyaluronic acid which received FDA approval in Dec. 2004. Hylaform® Hylaform Plus® are soft tissue fillers composed of hyaluronic acid extracted from rooster combs - both received FDA approval in 2004. Two additional tissue fillers composed of hyaluronic acid, Perlane® and Restylane® Fine Line, are used outside the United States but are not approved by the FDA.

Injectable Description Purpose Possible Side Effects/ Risks Results Regulatory Status
Restylane Non-animal derived hyaluronic acid. Soft tissue filler that adds volume. Redness, swelling, rare allergic reaction

Immediate, may last up to 1 year

FDA approved for filling moderate to severe wrinkles around the nose and mouth.

All other use considered off label.
Restylane Fine-lines Non-animal derived hyaluronic acid. Soft tissue filler that adds volume. Redness, swelling, tenderness, especially at sight of injection; acne-like formations are rare Immediate, may last up to 1 year In use outside U.S.

Not FDA approved for any use in the U.S.
Perlane Non-animal derived hyaluronic acid. Soft tissue filler that adds volume. Pain, redness, swelling, itching, discoloration, and tenderness at the point of injection Immediate may last up to 1 year; subsequent injections may require less Perlane In use outside U.S.

Not FDA approved for any use in the U.S.
Captique Non-animal derived hyaluronic acid. Soft tissue filler that adds volume. Bruising, swelling, rare allergic reaction Immediate, may last up to 1 year FDA approved for filling moderate to sever facial wrinkles and folds around the nose and mouth
Hylaform Hyaluronic acid extracted from rooster combs. Soft tissue filler that adds volume. Redness, swelling, people with sensitivities to avian products may have an allergic reaction Vary, may last up to 6 months FDA approved for filling moderate to severe wrinkles around the nose and mouth.

All other use considered off label.
Hylaform Plus  Hyaluronic acid extracted from rooster combs. Contains large hyaluronic gel acid particles. Soft tissue filler that adds volume. Redness, swelling, people with sensitivities to avian products may have an allergic reaction Vary, may last longer than 4-6 months FDA approved for filling moderate to severe wrinkles around the nose and mouth.

Semi-permanent Fillers

Two additional soft tissue fillers being studied for their wrinkle reducing and volume-adding qualities are Artecoll® and RadianceTM. Artecoll is a permanent “micro-implant” to fill facial wrinkles and lines, which is currently used in Europe, Canada and Mexico. Radiance is composed of calcium hydroxylapatite, which has been used in the body for multiple applications including cheek and chin implants. Radiance is injected into the face adding volume through microspheres that are suspended in polysaccharide carriers until encapsulation occurs. Another filler, Sculptra, which is made of synthetic polylactic acid contained in microspheres, can be used to restore volume to the face of HIV patients suffering from facial lipoatrophy.

Injectable Description Purpose Possible Side Effects/ Risks Results Regulatory Status
Artecoll 75% percent bovine collagen and 25% polymethyl-methacrylate microspheres (non-silicone, carbon–based polymers). Artecoll's manufacturer claims the injectable is permanent, as the microspheres do not absorb into the body. The body forms collagen around the microspheres that adds bulk. Lumping, granulomas (localized skin reactions to foreign bodies, which can appear as hardness or a rash), micro-spheres can possibly move to other areas of the body Immediate, need to wait 3 months between injections. FDA advisory panel recom-mended approval with conditions 2/03.

Contrain-dication for lip augment-ation.
Radiance (Bioform) Calcium hydroxyla-patite (a substance found in bone and teeth, made into an injectable paste) Reported to last 2-5 years. Little risk of allergic reaction. The body forms collagen around the microspheres that adds bulk. Clumping, lumping, granulomas, micro-spheres may move to other areas of the body. If injected next to bone, formation of bone can occur. Immediate according to manu-facturer. FDA approved only for vocal cord paralysis and urinary incontinence.

All other use considered off label.
Sculptra Synthetic polylactic acid contained in micro-spheres. Restores lost facial volume in people with HIV. The body forms collagen around the micro-spheres. Redness, bruising, lumping and granulomas Immediate, and typically last two years according to manu-facturer. Approved by FDA with condition that it be used to reconstruct HIV patients suffering from facial lipoatrophy.

In use outside the U.S. as New Fill, to fill wrinkles.

 

Matridur is an HA filler and can be used in exactly the same way as other HA's. It has 25% more HA, less endo toxins, is much easier to expel from the syringe than say restylane and costs less!
Matridex is the same product but has dextranamers (particles). These are all between 80-120 microns to prevent them moving from the site of injection. Further more they reduce to sugars within two years and are expelled from the body. This filler is ideal for candidates still producing collagen as the HA gives an initial filling and the collagen synthesis formed by the particles gives a treatment result of up to 18 months.

 

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